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FLASH GENE

Symbol

HSPB6

contributors: mct/pgu - updated : 08-09-2014

HGNC name	heat shock protein, alpha-crystallin-related, B6
HGNC id	26511

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism other	mutation P20L is associated with structural alterations, diminished phosphorylation at Ser16, and loss of the cardioprotective effects under stress conditions

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular     dual benefit of targeting HSPB6 in heart disease cardiovascular atheroma cardiac phosphorylation of HSPB6 at serine 16 may represent a potential therapeutic target in ischemic heart disease immunology infectious   may be a new therapeutic agent for the treatment of sepsis

ANIMAL & CELL MODELS