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FLASH GENE
Symbol HSD17B13 contributors: mct/npt - updated : 10-06-2009
HGNC name hydroxysteroid (17-beta) dehydrogenase 13
HGNC id 18685
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide sequence
  • an ADH_short domain
    • HOMOLOGY
    interspecies homolog to murine Hsd17b13 (82.7pc)
    homolog to rattus Hsb17b13 (81.0pc)
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • secreted protein
  • concentrated in some site of the cytoplasm, but not in the ER (Liu 2009)
    • basic FUNCTION
  • may have an oxidoreductase activity
  • involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics (Persson 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS