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FLASH GENE
Symbol HSD17B13 contributors: mct/npt - updated : 10-06-2009
HGNC name hydroxysteroid (17-beta) dehydrogenase 13
HGNC id 18685
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide sequence
  • an ADH_short domain
    • HOMOLOGY
    interspecies homolog to murine Hsd17b13 (82.7pc)
    homolog to rattus Hsb17b13 (81.0pc)
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • secreted protein
  • concentrated in some site of the cytoplasm, but not in the ER (Liu 2009)
    • basic FUNCTION
  • may have an oxidoreductase activity
  • involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics (Persson 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS