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FLASH GENE

Symbol

HSD17B13

contributors: mct/npt - updated : 10-06-2009

HGNC name	hydroxysteroid (17-beta) dehydrogenase 13
HGNC id	18685

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	19.10 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant A 7 - 2395 isoform a 33.5 300 - Liu (2007) variant B - - 2287 isoform b 29.5 264 - Liu (2007)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide sequence
	an ADH_short domain

HOMOLOGY

interspecies	homolog to murine Hsd17b13 (82.7pc)
	homolog to rattus Hsb17b13 (81.0pc)

Homologene

FAMILY

short-chain dehydrogenases/reductases (SDR) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
text	secreted protein
	concentrated in some site of the cytoplasm, but not in the ER (Liu 2009)

basic FUNCTION	may have an oxidoreductase activity
	involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics (Persson 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS