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FLASH GENE
Symbol HES3 contributors: mct - updated : 03-12-2010
HGNC name hairy and enhancer of split 3 (Drosophila)
HGNC id 26226
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 697 - 186 - 2004 15254753
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in the developing central nervous system, highly expressed by neural stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal basic helix-loop-helix domain
  • an orange domain
  • a proline-rich domain
  • a C-terminal WRPW motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription regulator activity
  • at later stages of development, promote gliogenesis
  • play an essential role in neural development by regulating proliferation, differentiation and specification of neural stem cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS