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FLASH GENE
Symbol HES3 contributors: mct - updated : 03-12-2010
HGNC name hairy and enhancer of split 3 (Drosophila)
HGNC id 26226
Location 1p36.31      Physical location : 6.304.251 - 6.305.638
Synonym name
  • novel protein, possible ortholog of rodent transcription factor HES- 3
  • class B basic helix-loop-helix protein 43
  • transcription factor HES-3
    • Synonym symbol(s) bHLHb43
    DNA
    TYPE functioning gene
    STRUCTURE 1.38 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 697 - 186 - 2004 15254753
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in the developing central nervous system, highly expressed by neural stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal basic helix-loop-helix domain
  • an orange domain
  • a proline-rich domain
  • a C-terminal WRPW motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription regulator activity
  • at later stages of development, promote gliogenesis
  • play an essential role in neural development by regulating proliferation, differentiation and specification of neural stem cells
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS