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FLASH GENE
Symbol PPP1CB contributors: mlc/npt - updated : 01-04-2016
HGNC name protein phosphatase 1, catalytic subunit, beta isoform
HGNC id 9282
Location 2p23.2      Physical location : 28.974.613 - 29.025.805
Synonym name
  • protein phosphatase 1-delta
  • serine/threonine protein phosphatase PP1-beta catalytic subunit
  • epididymis secretory sperm binding protein Li 80p
  • protein phosphatase 1, catalytic subunit, beta isoform
  • protein phosphatase 1, catalytic subunit, delta isoform
  • Synonym symbol(s) MGC3672, PP-1B, PPP1CD, HEL-S-80p, PP1B, PP1beta
    EC.number 3.1.3.16/ 3.1.3.53
    DNA
    TYPE functioning gene
    STRUCTURE 51.19 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a polymorphic (CA) repeat marker (D2S1237)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text three alternate splicing variants (Barker)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4991 37.2 327 - Flores-Delgado (2007)
    9 - 4786 37.2 327 - Flores-Delgado (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ppp1cb
    homolog to C.elegans F29f11.6
    intraspecies homolog to PPP1CA
    Homologene
    FAMILY
  • PPP family of phophatases
  • PP-1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • serine/threonine protein phosphatase 1, catalytic subunit, essentiel for cell division
  • regulating glycogen metabolism, muscle contractility, protein synthesis, ionic conductances and long-term synaptic plasticity
  • catalytic subunit of protein phosphatase 1
  • PPP1CA and PPP1CB - are capable of compensating the loss of PPP1CC in every tissue except in testis
  • CELLULAR PROCESS cell cycle, division
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • PPP1CB-NPM pathway contributes to cellular DNA damage response
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mn2+
  • protein
  • interacting with BRCA1 (contributing to the development of breast cancer)
  • interacted with TRIM28 only in response to genotoxic stress
  • physiological NPM phosphatase under both the genotoxic stress and growth conditions
  • MRAS and SHOC2 function as PPP1CB regulatory subunits providing the complex with striking specificity against RAF
  • PPP1CB and UBAC1 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    YPEL5/PPP1CB in Chronic lymphocytic leukemia (CLL) with N-terminal truncation caused by YPEL5/PPP1CB fusion decreasing the phosphatase activity of PPP1CB enzyme
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS