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FLASH GENE
Symbol FAM57B contributors: mct - updated : 08-04-2015
HGNC name family with sequence similarity 57, member B
HGNC id 25295
DNA
TYPE functioning gene
STRUCTURE 28.58 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1943 - 274 - 2013 23275342
down-regulated in obese adipose tissue
- - - - - - 2013 23275342
  • only FAM57B variant 2 is directly targeted by PPARG and could regulate adipogenesis through ceramide metabolism
  • might also be regulated by phosphorylated PPARG
  • plays a role in de novo synthesis of ceramide
    • - - - - - - 2013 23275342
    down-regulated in obese adipose tissue
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one TLC (TRAM/LAG1/CLN8) domain, that is related to ceramide synthase
    • HOMOLOGY
    interspecies homolog to rattus rgd1308215
    Homologene
    FAMILY FAM57 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • distributed in the ER and Golgi
    • basic FUNCTION
  • regulates adipogenesis through ceramide synthesis
  • FAM57B interferes with adipogenesis by augmenting ceramide synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPARG-responsive transmembrane gene that is related to obesity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS