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FLASH GENE

Symbol

GNL3L

contributors: mct - updated : 04-11-2011

HGNC name	guanine nucleotide binding protein-like 3 (nucleolar)-like
HGNC id	25553

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon       liver           mouth tongue     highly Lymphoid/Immune spleen         Reproductive female system uterus cervix   highly   male system prostate

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a circularly permuted G-motif described by a G5-G4-G1-G2-G3 pattern similar to the HSR1/MMR1 GTP-binding protein subfamily
	lysine-rich nucleolar localization signal (NoLS) residing within 1-50 amino acid residues, for the transport in the nucleole (necessary and sufficient to target the heterologous proteins to the nucleolus)

HOMOLOGY

interspecies	homolog to murine Gnl3l (88.2pc)

intraspecies

paralog to nucleostemin

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	putative GTPase activity
	is required for growth and plays a role in processing of nucleolar pre-rRNA
	composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus
	is able to reduce the steroid receptor coactivator (SRC) binding and the SRC-mediated transcriptional coactivation of ESRRG
	TERF1 protein-stabilizing activity of GNL3L mediates the mitotic increase of TERF1 protein and promotes the metaphase-to-anaphase transition
	GNL3L and nucleostemin are the only two that are designed to stabilize MDM2 protein under basal or induced condition, respectively, and may act as tumor-promoting genes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP binding

protein	TERF1-interacting protein (binds TERF1 in the nucleoplasm and is capable of promoting the homodimerization and telomeric association of TERF1, preventing promyelocytic leukemia body recruitment of telomere-bound TERF1)
	MDM2 regulator (GNL3L binds MDM2 and displays the same function as nucleostemin in stabilizing MDM2 protein and preventing its ubiquitylation)
	TERF1 dimerization is actively and oppositely regulated by GNL3 and GNL3L extrachromosomally

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS