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FLASH GENE
Symbol ALG13 contributors: mct - updated : 17-01-2015
HGNC name asparagine-linked glycosylation 13 homolog (S. cerevisiae)
HGNC id 30881
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal beta-strand having an important rolein protein stability
  • short C-terminal alpha-helix required for interaction with ALG14 and for enzyme activity
    • HOMOLOGY
    interspecies homolog to murine Glt28d1 (86.7pc)
    Homologene
    FAMILY
  • glycosyltransferase 28 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • ALG14 recruits cytosolic ALG13 to the ER membrane through interaction between their C-termini
    • basic FUNCTION
  • may be involved in N-linked glycosylation
  • second step of eukaryotic N-linked glycosylation in endoplasmic reticulum is catalyzed by an UDP-N-acetylglucosamine transferase that is comprised of two subunits, ALG13 and ALG14
  • subunit of the uridine diphosphate-N-acetylglucosamine transferase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between ALG13 and 14 is crucial for UDP-GlcNAc transferase activity, so formation of the ALG13/14 complex is likely to play a key role in the regulation of N-glycosylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1S , MRX80 , EIEE36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS