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FLASH GENE

Symbol

ALG13

contributors: mct - updated : 17-01-2015

HGNC name	asparagine-linked glycosylation 13 homolog (S. cerevisiae)
HGNC id	30881

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach         Endocrine parathyroid         Lymphoid/Immune lymph node         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal beta-strand having an important rolein protein stability
	short C-terminal alpha-helix required for interaction with ALG14 and for enzyme activity

HOMOLOGY

interspecies

homolog to murine Glt28d1 (86.7pc)

Homologene

FAMILY

glycosyltransferase 28 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
text	ALG14 recruits cytosolic ALG13 to the ER membrane through interaction between their C-termini

basic FUNCTION	may be involved in N-linked glycosylation
	second step of eukaryotic N-linked glycosylation in endoplasmic reticulum is catalyzed by an UDP-N-acetylglucosamine transferase that is comprised of two subunits, ALG13 and ALG14
	subunit of the uridine diphosphate-N-acetylglucosamine transferase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction between ALG13 and 14 is crucial for UDP-GlcNAc transferase activity, so formation of the ALG13/14 complex is likely to play a key role in the regulation of N-glycosylation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG1S , MRX80 , EIEE36

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS