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FLASH GENE
Symbol HPDL contributors: mct - updated : 30-09-2020
HGNC name 4-hydroxyphenylpyruvate dioxygenase-like
HGNC id 28242
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • 4HPPD family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • is a mitochondrial protein
    • basic FUNCTION
  • encodes a protein that may function like 4-hydroxyphenylpyruvate dioxygenase
  • is an important enzyme in the catabolic pathway of tyrosine in the liver
  • might play a role in oxidative phosphorylation (OXPHOS)
  • having dioxygenase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HPDLD , SPG83
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    HPDL were down-regulated in HCC (hepatocellular carcinoma)cell lines through promoter methylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CNV of HPDL is not only related to the patient's prognosis, but also related to gene methylation and expression levels affecting the patient's survival time in breast cancer
    • Therapy target
    ANIMAL & CELL MODELS