Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HPDL contributors: mct - updated : 30-09-2020
HGNC name 4-hydroxyphenylpyruvate dioxygenase-like
HGNC id 28242
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Reproductivefemale systemplacenta   
 female systemuteruscervix  
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • 4HPPD family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • is a mitochondrial protein
  • basic FUNCTION
  • encodes a protein that may function like 4-hydroxyphenylpyruvate dioxygenase
  • is an important enzyme in the catabolic pathway of tyrosine in the liver
  • might play a role in oxidative phosphorylation (OXPHOS)
  • having dioxygenase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HPDLD , SPG83
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    HPDL were down-regulated in HCC (hepatocellular carcinoma)cell lines through promoter methylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CNV of HPDL is not only related to the patient's prognosis, but also related to gene methylation and expression levels affecting the patient's survival time in breast cancer
  • Therapy target
    ANIMAL & CELL MODELS