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FLASH GENE

Symbol

GLDN

contributors: mct - updated : 23-11-2016

HGNC name	gliomedin
HGNC id	29514

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an olfactomedin (OLF) domain located at the extracellular C-terminus, involved in the accumulation of neuronal plasma membrane voltage-gated sodium channels in the nodes by interacting with NFASC and NRCAM

HOMOLOGY

interspecies	homolog to murine Gldn (88.2pc)
	homolog to rattus Gldn (86.6pc)

Homologene

FAMILY

CATEGORY

adhesion , signaling

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	providing a glial cue for the formation of peripheral nodes of Ranvier
	is one of the essential proteins in the development of the nodes of Ranvier in the vertebrate peripheral nervous system
	secreted cell adhesion molecule involved in the formation of the nodes of Ranvier
	major role of gliomedin in node formation and the development of the peripheral nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	initial clustering of Na(+) channels at heminodes requires glial NRCAM and GLDN, as well as their axonal receptor neurofascin 186 (NFASC186)
	in the peripheral nervous system (PNS), the axoglial contact mediated by the binding of glial GLDN and NRCAM to axonal NFASC186 is crucial for the initial clustering of voltage-gated Na+ channels at the nodes of Ranvier
	axoglial contact between GLDN and NFASC186 is essential for the initial clustering of Na+ channels at developing nodes

cell & other

interacting with neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LCCS11

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         upregulated in hepatocytes throughout the tumor and in preneoplastic foci

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS