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FLASH GENE
Symbol ADRA1D contributors: mct - updated : 19-09-2018
HGNC name adrenergic, alpha-1D-, receptor
HGNC id 280
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • two N-linked glycosylation sites in its N terminus
  • a transmembrane region
  • several phosphorylation sites in its C terminus
    • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies ortholog to rattus Adra1d
    ortholog to murine Adra1d
    homolog to drosophila oamb
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
    • basic FUNCTION
  • mediating its effect through the influx of extracellular
    • calcium
  • acting through the phosphadidylinositol/Ca2+ second messenger system
  • mediating G1-S cell-cycle
  • is a key regulator of sympathetic nervous system function
  • syntrophin and utrophin associate with ADRA1D to create a functional signalosome, which is essential for ADRA1D regulation of vascular tone and blood pressure
  • ADRA1D expression is essential for skeletal muscle cell survival
  • cross-talk between ADARA1D and TRPV1, that is involved in the control of prostate carcinoma cell proliferation
  • G protein-coupled receptors that mediate adrenaline/noradrenaline actions
  • is a key regulator of cardiovascular, prostate, and central nervous system functions
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • positif regulation of cell proliferation
    • PATHWAY
    metabolism nucleic
    signaling signal transduction
  • DNA metabolism
  • cell-cell signaling
    • a component
  • modular dimeric architecture for the ADRA1D in the cell membrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • syntrophin, dystrobrevin, and utrophin as essential GPCR-interacting proteins for ADRA1D
  • induces vascular smooth muscle apoptosis via a TP53-dependent mechanism
  • inhibition of vascular smooth muscle ADRBK1 enhances ADRA1D-adrenergic receptor constriction
  • ADRA1D-a key regulator of cardiovascular, urinary and CNS function-binds the syntrophin family of PDZ domain proteins (SNTA, SNTB1, and SNTB2) through a C-terminal PDZ ligand interaction, ensuring receptor plasma membrane localization and G-protein coupling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    selective ADRA1B antagonist inhibits prostate cancer cell proliferation and motility
    ANIMAL & CELL MODELS