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FLASH GENE
Symbol FER1L5 contributors: mct - updated : 28-01-2009
HGNC name fer-1-like 5 (C. elegans)
HGNC id 19044
Location 2q11.2      Physical location : 97.308.573 - 97.370.623
Synonym name fer-1-like 5
Synonym symbol(s) DKFZp434I0121
DNA
TYPE functioning gene
MAPPING cloned Y linked N status provisional
Map cen - D2S2159 - D2S113 - FER1L5 - D2S2222 - D2S2175 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2536 93.3 802 - -
- - 6477 241.8 2093 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2 domains
  • contain an NPF motif
  • HOMOLOGY
    interspecies homolog to rattus Fer1l5 (74.6 pc)
    homolog to murine Fer1l5
    intraspecies homolog to high homology to dysferlin and myoferlin
    Homologene
    FAMILY
  • ferlin family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • expressed in small myotubes that contain only two to four nuclei
  • basic FUNCTION
  • EHD proteins and ferlin proteins form discrete structures in myoblasts
  • ferlins are calcium-sensing proteins and are candidate mediators of vesicle-plasma membrane fusion during myoblast fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds directly to the endocytic recycling proteins EHD1 and EHD2 and the second C2 domain in FER1L5 mediates this interaction
  • ferlin proteins interact with EHD proteins to mediate the cytoskeletal rearrangements necessary for proper membrane recycling and myoblast fusion
  • ferlins and EHBP1 may compete for EHD binding to regulate the complex process of exit from the endocytic recycling compartment, translocation to the plasma membrane, and reorganization of the actin cytoskeleton to facilitate the fusion of exocytosed vesicles to the membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS