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FLASH GENE
Symbol ADAT2 contributors: mct - updated : 12-09-2023
HGNC name adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae)
HGNC id 21172
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a AAA type ATPase domain
  • a bromodomain
    • HOMOLOGY
    interspecies homolog to S.Cerevisiae Tad2
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminase family
  • ADAT2 subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acts potentially on upstream and basic cellular processes to enhance oncogenesis in a variety of unrelated cell types
  • controls chromatin dynamics, genome transcriptional activities and apoptotic cell response
  • its overexpression in somatic cells, by acting on basic properties of chromatin, may contribute to malignant transformation
  • key role for the inactive ADAT3 deaminase domain in proper assembly with ADAT2, demonstrating that ADAT2/3 nuclear import is required for maintaining proper levels of the wobble inosine modification in tRNA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric enzyme ADAT (hetADAT), is composed of two subunits: ADAT2 and ADAT3 (ADAT2 is considered the catalytic subunit while ADAT3 might be playing a role in tRNA substrate recognition)
  • heterodimer ADAT3 / ADAT2 is involved in the adenosine-to-inosine conversion in tRNA
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ADAT2, is proposed as a predictive biomarker of efficacy of treatments recently recommended to patients with BRCA1 deficiency
    • Therapy target
    ANIMAL & CELL MODELS