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FLASH GENE
Symbol ADAT2 contributors: mct - updated : 12-09-2023
HGNC name adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae)
HGNC id 21172
Location 6q24.2      Physical location : 143.743.969 - 143.771.841
Synonym name
  • tumor necrosis factor receptor superfamily member 6 precursor
  • apoptosis-mediating surface antigen FAS
  • CD95 antigen
  • FASLG receptor
  • Apo-1 antigen
  • deaminase domain containing 1
  • tRNA-specific adenosine deaminase 2 homolog (S. cerevisiae)
    • Synonym symbol(s) dJ20N2.1, FLJ44213, DKFZp686L1118, TNFRSF6, FAS1, APT1, DEADC1, TAD2, ATAD2
    EC.number 3.5.4.33
    DNA
    TYPE functioning gene
    STRUCTURE 27.87 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 6270 21 191 - 2010 2058186
    6 - 7351 - 144 - 2010 2058186
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a AAA type ATPase domain
  • a bromodomain
    • HOMOLOGY
    interspecies homolog to S.Cerevisiae Tad2
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminase family
  • ADAT2 subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acts potentially on upstream and basic cellular processes to enhance oncogenesis in a variety of unrelated cell types
  • controls chromatin dynamics, genome transcriptional activities and apoptotic cell response
  • its overexpression in somatic cells, by acting on basic properties of chromatin, may contribute to malignant transformation
  • key role for the inactive ADAT3 deaminase domain in proper assembly with ADAT2, demonstrating that ADAT2/3 nuclear import is required for maintaining proper levels of the wobble inosine modification in tRNA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric enzyme ADAT (hetADAT), is composed of two subunits: ADAT2 and ADAT3 (ADAT2 is considered the catalytic subunit while ADAT3 might be playing a role in tRNA substrate recognition)
  • heterodimer ADAT3 / ADAT2 is involved in the adenosine-to-inosine conversion in tRNA
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ADAT2, is proposed as a predictive biomarker of efficacy of treatments recently recommended to patients with BRCA1 deficiency
    • Therapy target
    ANIMAL & CELL MODELS