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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

E2F1

contributors: mct/shn - updated : 26-07-2022

HGNC name	E2F transcription factor 1
HGNC id	3113

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in metastatic tissues from hormone-resistant prostate cancer patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     E2F1-DUSP2 cascade in cancer cell killing may provide a molecular basis for cancer therapeutic intervention diabete type 2   specifically targeting E2F1 in the liver could be an interesting strategy for therapies against type 2 diabetes

ANIMAL & CELL MODELS

E2f1-deficient mice exhibit defects in apoptosis and are rather prone to tumorigenesis