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FLASH GENE
Symbol NCLN contributors: mct/ - updated : 22-04-2006
HGNC name nicalin homolog (zebrafish)
HGNC id 26923
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a VWFC domain
    • mono polymer trimer
    HOMOLOGY
    Homologene
    FAMILY
  • fibrillar collagen family
  • nicastrin family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text colocalizes with TMEM147 and NOMO in the endoplasmic reticulum (ER)
    basic FUNCTION
  • controlling the assembly and stability of the Nicalin-NOMO complex
  • forming the fibrils of tendon, ligaments and bones (in bones the fibrils are mineralized with calcium hydroxyapatite)
  • not only controls NOMO1, NOMO2, NOMO3, but also TMEM147 expression levels, corroborating the idea that it represents the rate-limiting factor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • trimers of one alpha 2(I) and two alpha 1(I) chains
  • forms a complex with NOMO (complex antagonizing NODAL signaling during mesendodermal patterning)
  • part of Nicalin-NOMO-TMEM147 complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TMEM147, nicalin, and NOMO
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS