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FLASH GENE
Symbol NCLN contributors: mct/ - updated : 22-04-2006
HGNC name nicalin homolog (zebrafish)
HGNC id 26923
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon highly
Reproductivefemale systemuteruscervix highly
 female systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a VWFC domain
    • mono polymer trimer
    HOMOLOGY
    Homologene
    FAMILY
  • fibrillar collagen family
  • nicastrin family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text colocalizes with TMEM147 and NOMO in the endoplasmic reticulum (ER)
    basic FUNCTION
  • controlling the assembly and stability of the Nicalin-NOMO complex
  • forming the fibrils of tendon, ligaments and bones (in bones the fibrils are mineralized with calcium hydroxyapatite)
  • not only controls NOMO1, NOMO2, NOMO3, but also TMEM147 expression levels, corroborating the idea that it represents the rate-limiting factor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • trimers of one alpha 2(I) and two alpha 1(I) chains
  • forms a complex with NOMO (complex antagonizing NODAL signaling during mesendodermal patterning)
  • part of Nicalin-NOMO-TMEM147 complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TMEM147, nicalin, and NOMO
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS