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FLASH GENE

Symbol

NCLN

contributors: mct/ - updated : 22-04-2006

HGNC name	nicalin homolog (zebrafish)
HGNC id	26923

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	23.70 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020170 15 - 3749 NP_064555 - 563 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   intestine large intestine colon   highly Reproductive female system uterus cervix   highly   female system ovary     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a VWFC domain

mono polymer

trimer

HOMOLOGY

Homologene

FAMILY	fibrillar collagen family
	nicastrin family

CATEGORY

regulatory , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	colocalizes with TMEM147 and NOMO in the endoplasmic reticulum (ER)

basic FUNCTION	controlling the assembly and stability of the Nicalin-NOMO complex
	forming the fibrils of tendon, ligaments and bones (in bones the fibrils are mineralized with calcium hydroxyapatite)
	not only controls NOMO1, NOMO2, NOMO3, but also TMEM147 expression levels, corroborating the idea that it represents the rate-limiting factor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	trimers of one alpha 2(I) and two alpha 1(I) chains
	forms a complex with NOMO (complex antagonizing NODAL signaling during mesendodermal patterning)
	part of Nicalin-NOMO-TMEM147 complex

INTERACTION

DNA

RNA

small molecule

protein

interaction between TMEM147, nicalin, and NOMO

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS