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FLASH GENE
Symbol NCLN contributors: mct/ - updated : 22-04-2006
HGNC name nicalin homolog (zebrafish)
HGNC id 26923
Location 19p13.3      Physical location : 3.185.874 - 3.209.572
Synonym name
  • nicalin
  • nicastrin-like protein
    • Synonym symbol(s) NICALIN, NET59
    DNA
    TYPE functioning gene
    STRUCTURE 23.70 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3749 - 563 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a VWFC domain
    • mono polymer trimer
    HOMOLOGY
    Homologene
    FAMILY
  • fibrillar collagen family
  • nicastrin family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text colocalizes with TMEM147 and NOMO in the endoplasmic reticulum (ER)
    basic FUNCTION
  • controlling the assembly and stability of the Nicalin-NOMO complex
  • forming the fibrils of tendon, ligaments and bones (in bones the fibrils are mineralized with calcium hydroxyapatite)
  • not only controls NOMO1, NOMO2, NOMO3, but also TMEM147 expression levels, corroborating the idea that it represents the rate-limiting factor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • trimers of one alpha 2(I) and two alpha 1(I) chains
  • forms a complex with NOMO (complex antagonizing NODAL signaling during mesendodermal patterning)
  • part of Nicalin-NOMO-TMEM147 complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TMEM147, nicalin, and NOMO
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS