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FLASH GENE
Symbol CXCL5 contributors: mct - updated : 18-03-2008
HGNC name chemokine (C-X-C motif) ligand 5
HGNC id 10642
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY intercrine alpha family
CATEGORY signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
text both CXCL5 and CXCR2 were localized in the tunica intima and tunica adventitia of blood vessels in adipose tissue
basic FUNCTION
  • involved in neutrophil activation
  • promote angiogenesis related to cancer
  • exhibited chemoattractant and angiogenic properties (
  • exerts chemoattraction through CXCR2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CXCL5/CXCR2 axis is likely responsible for the therapeutic effects via angiogenesis
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by IL-1alpha or TNF-alpha stimulation in corneal cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    CXCL5 expression/secretion could contribute to adipose tissue-derived stem cells therapeutic potential by promoting angiogenesis in ischemic tissues
    ANIMAL & CELL MODELS