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FLASH GENE

Symbol

CRBN

contributors: mct/npt - updated : 24-06-2015

HGNC name	cereblon
HGNC id	30185

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRT2A

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	CamKII(cre/+), crbn(-/-) mice exhibit selective hipoccapus-dependent deficits in associative learning and supports the use of these mice to study the functional consequences of CRBN aberrations on memory and learning in humans
	mice with CRL4A(CRBN) mutation in the brain or treated with
	a CRBN inhibitor are very sensitive to seizure induction, which can be attenuated by blocking KCNMA1 channels