| SUBCELLULAR LOCALIZATION
| plasma membrane,junction,tight
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| plasma membrane,junction,adherens
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| intracellular
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytoskeleton,microfilament
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| text
| concentrated in the junctional complex in various types of epithelial and endothelial cells |
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Furthermore, in the liver and kidney, also distributed along non-junctional actin filaments |
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is peripherally localized in isolated cells, requires the integrity of the microtubule cytoskeleton to be stably anchored to junctions  |
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localized in the cytoplasmic region of epithelial tight and adherens junctions |
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CGN, CGNL1 and PLEKHA7 are proteins localized in the cytoplasmic region of the apical junctional complex of vertebrate epithelial cells |
| basic FUNCTION
| involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons |
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regulates the activity of RAC1 and RHOA GTPases by recruiting TIAM1 and ARHGEF2 to epithelial junctions |
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CGN and CGNL1 regulate Rho family GTPases by recruiting guanine nucleotide exchange factors to epithelial junctions |
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CGN1 and CGNL1 show a similar dynamic behaviour, but partially distinct localizations and functional interactions with the cytoskeleton, and are recruited independently to junctions |
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component of the macromolecular complex that links adherens junctions to microtubules, and PLEKHA7, and, to a lesser extent, TJP1, are required to recruit paracingulin to epithelial junctions efficiently |
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PLEKHA7, together with CNGL1, is part of a protein complex that links CDH1 to the microtubule cytoskeleton at AJs |
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functional relevance for CGNL1 as a defining factor in new vessel formation |
