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FLASH GENE

Symbol

CGNL1

contributors: mct - updated : 26-11-2018

HGNC name	cingulin-like 1
HGNC id	25931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	112.74 kb     18 Exon(s)

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	a TATA-less promoter including a transcription initiator cap sequence and multiple DNA motifs that bind transcription factors

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - CYP19A1 - TMOD3 - CGNL1 - qter
Authors	Shozu et al.(03)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032866 18 - 7235 160 1302 - 2004 15292197 NM_001252335 - - 7353 - 1302 - 2004 15292197

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Lymphoid/Immune spleen         Nervous brain diencephalon amygdala       brain basal nuclei corpus callosum       brain diencephalon thalamus     Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular smooth

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal region containing a conserved ZIM (ZO-1-Interaction-Motif) sequence

HOMOLOGY

interspecies

homolog to murine Cgnl1

Homologene

FAMILY

CATEGORY

adaptor , chaperone/stress

SUBCELLULAR LOCALIZATION	plasma membrane,junction,tight
	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytoskeleton,microfilament
text	concentrated in the junctional complex in various types of epithelial and endothelial cells
	Furthermore, in the liver and kidney, also distributed along non-junctional actin filaments
	is peripherally localized in isolated cells, requires the integrity of the microtubule cytoskeleton to be stably anchored to junctions
	localized in the cytoplasmic region of epithelial tight and adherens junctions
	CGN, CGNL1 and PLEKHA7 are proteins localized in the cytoplasmic region of the apical junctional complex of vertebrate epithelial cells

basic FUNCTION	involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons
	regulates the activity of RAC1 and RHOA GTPases by recruiting TIAM1 and ARHGEF2 to epithelial junctions
	CGN and CGNL1 regulate Rho family GTPases by recruiting guanine nucleotide exchange factors to epithelial junctions
	CGN1 and CGNL1 show a similar dynamic behaviour, but partially distinct localizations and functional interactions with the cytoskeleton, and are recruited independently to junctions
	component of the macromolecular complex that links adherens junctions to microtubules, and PLEKHA7, and, to a lesser extent, TJP1, are required to recruit paracingulin to epithelial junctions efficiently
	PLEKHA7, together with CNGL1, is part of a protein complex that links CDH1 to the microtubule cytoskeleton at AJs
	functional relevance for CGNL1 as a defining factor in new vessel formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	forms a complex with the tight junction protein TJP1, and the globular head domain of paracingulin interacts directly with TJP1 through an N-terminal region containing a conserved ZIM (ZO-1-Interaction-Motif) sequence
	forms a complex with PLEKHA7 and its interacting partner CTNND1, and the globular head domain of paracingulin interacts directly with a central region of PLEKHA7
	SH3BP1 formed a complex with CGNL1/paracingulin, a junctional adaptor, and CD2AP, a scaffolding protein, and both were required for normal CDC42 signaling and junction formation

INTERACTION

DNA

RNA

small molecule

protein	regulator of the activity of two small GTPases, RAC1 and RHOA, through the functional interaction with their respective activators, TIAM1 and ARHGEF2
	associates with E-cadherin, CDH1
	TJP1 and the adherens junction protein PLEKHA7 as paracingulin-binding proteins
	one function of CGN and CGNL1 is to regulate the activity of Rho family GTPases at junctions through their direct interaction with guanidine exchange factors of RHOA and RAC1
	CGN and CGNL1 control RHOA activation in epithelial cells by interacting with RHOA guanidine exchange factors
	regulates vascular growth by promoting CDH5 association with the actin cytoskeleton, thereby stabilizing adherens junctions

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS