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FLASH GENE
Symbol FAM101A contributors: mct - updated : 11-04-2012
HGNC name family with sequence similarity 101, member A
HGNC id 27051
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2160 - 135 - 2011 21709252
EXPRESSION
Rna function mRNA is up-regulated during the commitment of multipotent neural precursor cells into glial progenitor cells
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • enriched in proline with a secondary structure predicted to be composed of beta structures and coiled domains lacking alpha helices
  • N-terminal sequence harboring a DSG(X)2–4S motif mediating degradation of short-lived proteins and also found in nuclear transcription factors involved in TGFB–dependent EMT signaling
  • at least two FLNA binding domains (BD2 and BD4)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • specifically promote actin filament bundles to organize apical perinuclear actin networks in mesenchymal cells
  • function through binding to the actin binding protein FLNA and conversion of FLNA from an F-actin branching protein into an F-actin bundler
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RefilinA/RefilinB/FLNA complex organizes the perinuclear actin filament bundles forming the actin cap
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to the actin-binding filamins, FLNA, FLNB, and FLNC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS