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FLASH GENE

Symbol

FAM101A

contributors: mct - updated : 11-04-2012

HGNC name	family with sequence similarity 101, member A
HGNC id	27051

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	26.86 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_181709 3 - 2160 NP_859060 - 135 - 2011 21709252

EXPRESSION

Rna function	mRNA is up-regulated during the commitment of multipotent neural precursor cells into glial progenitor cells
Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	enriched in proline with a secondary structure predicted to be composed of beta structures and coiled domains lacking alpha helices
	N-terminal sequence harboring a DSG(X)2–4S motif mediating degradation of short-lived proteins and also found in nuclear transcription factors involved in TGFB–dependent EMT signaling
	at least two FLNA binding domains (BD2 and BD4)

HOMOLOGY

Homologene

FAMILY

CATEGORY

SUBCELLULAR LOCALIZATION

basic FUNCTION	specifically promote actin filament bundles to organize apical perinuclear actin networks in mesenchymal cells
	function through binding to the actin binding protein FLNA and conversion of FLNA from an F-actin branching protein into an F-actin bundler

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

RefilinA/RefilinB/FLNA complex organizes the perinuclear actin filament bundles forming the actin cap

INTERACTION

DNA

RNA

small molecule

protein

bind to the actin-binding filamins, FLNA, FLNB, and FLNC

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS