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FLASH GENE

Symbol

NRG4

contributors: - updated : 05-04-2006

HGNC name	neuregulin 4
HGNC id	29862

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	69.00 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue       Endocrine adrenal gland           pancreas         Reproductive male system testis       Respiratory respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an EGF-like domain
	a short cytoplasmic domain

HOMOLOGY

Homologene

FAMILY

neuregulin family

CATEGORY

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

may be involved in the regulation of trafficking and proteolytic processing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	low affinity ligand for the ERBB4 tyrosine kinase receptor
	recruiting ERBB1 and ERBB2 coreceptors, resulting
	in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in bladder cancer with favourable outcome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS