Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NRG4 contributors: - updated : 05-04-2006
HGNC name neuregulin 4
HGNC id 29862
Location 15q24.2      Physical location : 76.234.329 - 76.304.785
Synonym name
  • heregulin 4
  • pro-neuregulin-4, membrane-bound isoform
  • Synonym symbol(s) HRG4, Pro-NRG4
    DNA
    TYPE functioning gene
    STRUCTURE 69.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Endocrineadrenal gland    
     pancreas    
    Reproductivemale systemtestis   
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an EGF-like domain
  • a short cytoplasmic domain
  • HOMOLOGY
    Homologene
    FAMILY neuregulin family
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in the regulation of trafficking and proteolytic processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • low affinity ligand for the ERBB4 tyrosine kinase receptor
  • recruiting ERBB1 and ERBB2 coreceptors, resulting
  • in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder cancer with favourable outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS