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FLASH GENE
Symbol LAMB2 contributors: mct - updated : 26-02-2011
HGNC name laminin, beta 2 (laminin S)
HGNC id 6487
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 4 laminin A/neurexin/sex hormone-binding (LNS) globular domains separated by
  • 13 EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI)
  • a long arm composed of heptad repeats typical of an cell alpha helical coiled-coil protein
  • C-terminal region of beta chains is involved in laminin recognition by integrins and modulates the binding affinities of laminins toward X2-type integrins
    • conjugated GlycoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Lamb2 (88.04 pc)
    homolog to murine Lamb2 (88.42 pc)
    intraspecies homolog to LAMB1
    Homologene
    FAMILY
  • laminin family
    • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text glomeruli, nerve fascicle perineurium, vascular, basement membrane of neuromuscular junction (matrix and synaptic cleft of the neuromuscular junction)
    basic FUNCTION
  • mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
  • playing a role in anchoring as well as differentiation of podocytes foot processes
  • basement membrane protein laminin beta2, which is incorporated in specific heterotrimeric laminin isoforms
  • essential component of the basement membrane
    • CELLULAR PROCESS cell life, differentiation
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of basement membrane zone
  • heterotrimerizing with laminin alpha and laminin gamma subunits
  • bêta subunit of laminin 3, laminin 4, laminin 7, laminin 11, laminin 13 and laminin 15
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to voltage-gated calcium channels
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCNS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS