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FLASH GENE

Symbol

ALKBH2

contributors: mct - updated : 26-06-2019

HGNC name	alkB, alkylation repair homolog 2 (E. coli)
HGNC id	32487

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q24.11      Physical location : 109.525.992 - 109.531.293
Synonym name	2OG-Fe(II) oxy DC1
	alkB, alkylation repair homolog 2
Synonym symbol(s)	ABH2, MGC90512

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Alkbh2

Homologene

FAMILY

alkB family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	strictly nuclear and located in replication foci during S-phase

basic FUNCTION	removing 1-methyladenine and 3-methylcytosine from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction, and act by direct damage reversal with the regeneration of the unsubstituted bases
	co-localize with proliferating cell nuclear antigen (PCNA) in replication foci during S-phase and may have a role in genome maintenance near replication forks
	ALKBH2-3 and ALKBH7 correct methyl and etheno adducts in DNA

CELLULAR PROCESS

nucleotide, repair

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS