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FLASH GENE

Symbol

CTRB2

contributors: mct - updated : 09-11-2021

HGNC name	chymotrypsinogen B2
HGNC id	2522

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q23.1      Physical location : 75.237.994 - 75.241.072
Synonym symbol(s)	FLJ42412
EC.number	3.4.21.1

DNA

TYPE	functioning gene
STRUCTURE	3.06 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001025200 7 - 870 NP_001020371 - 263 - - CTRB2 delta 6 6 - - - 166 - - deletion allele of the 584 bp exon 6 structural variant creates a premature stop codon yielding a 166aa protein (148aa after the signal peptide is removed) lacking chain C. structural variant overlapping CTRB2 exon 6 is a functional variant underlying risk for pancreatic cancer at chr16q23.1;this 584 bp genomic deletion results in intracellular accumulation of a nonfunctional CTRB2 protein leading to ER stress

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

first 18AA comprise a signal peptide that is cleaved off the zymogen upon entry into the ER

isoforms

Precursor

of pancreatic proteolytic enzymes

HOMOLOGY

interspecies

homolog to murine Ctrb1

intraspecies

paralog to CTRB1

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	peptidase activity
	playing a key role in the enteroendocrine system (
	involved in the regulation of the incretin pathway, development of diabetes, and response to DPP-4 inhibitor treatment (

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP/GTP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to pancreatic cancer to diabetes mellitus

Variant & Polymorphism other	increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles, impairing chymotrypsin B2 function and localization
	CTRB2 deletion variant associated with risk of diabetes mellitus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS