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FLASH GENE

Symbol

LAS1L

contributors: mct - updated : 10-10-2017

HGNC name	LAS1-like (S. cerevisiae)
HGNC id	25726

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

WTS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   leads to inhibition of rRNA processing and failure to synthesize the mature 28S rRNA constitutional     --low   affects cell proliferation and specifically the G1- to S-phase progression of the cell cycle constitutional germinal mutation       in spinal muscular atrophy with respiratory distress (SMARD)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS