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FLASH GENE
Symbol LAS1L contributors: mct - updated : 10-10-2017
HGNC name LAS1-like (S. cerevisiae)
HGNC id 25726
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glutamic acid-rich region on its C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • LAS1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text
  • found to localize predominantly in the nucleolus
  • localized mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export
    • basic FUNCTION
  • involved in cell morphogenesis and cell surface growth
  • nucleolar protein required for ribosome biogenesis, essential for cell proliferation and biogenesis of the 60S ribosomal subunit
  • affects cell proliferation through its fundamental role in ribosome biogenesis
  • required for the formation of the 60S ribosomal subunit, which contains the processed 28S rRNA
  • nucleolar protein required for maturation of the 60S preribosomal subunit
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PELP1 and the PELP1-associated factor LAS1L are SENP3-sensitive targets of SUMO
  • interacts with PELP1 and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WTS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    leads to inhibition of rRNA processing and failure to synthesize the mature 28S rRNA
    constitutional     --low  
    affects cell proliferation and specifically the G1- to S-phase progression of the cell cycle
    constitutional germinal mutation      
    in spinal muscular atrophy with respiratory distress (SMARD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS