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FLASH GENE

Symbol

LHX8

contributors: mct - updated : 24-03-2021

HGNC name	LIM homeobox 8
HGNC id	28838

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene for the isolated non syndromic form of cleft palate in humans (Zhao 1999)
Marker
Therapy target

ANIMAL & CELL MODELS

	mice with a null mutation of Lhx8 are deficient in development of forebrain cholinergic neurons (Zhao 2003)
	in Lhx8 -/- mice, ovaries lacked germ cells and appeared histologically identical to adult Sohlh1 -/- ovaries (Pangas 2006)