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FLASH GENE
Symbol LHX8 contributors: mct - updated : 24-03-2021
HGNC name LIM homeobox 8
HGNC id 28838
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two LIM zinc-binding domains
  • one homeodomain
    • HOMOLOGY
    interspecies homolog to rattus lhx8 (97.2pc)
    homolog to murine Lhx8 (96.6pc)
    Homologene
    FAMILY
  • LIM homeobox gene family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • (NOBOX) and LIM homeobox protein 8 (LHX8), two important regulators of postnatal oogenesis, were coexpressed with SOHLH1
    • basic FUNCTION
  • having a pivotal and specific role in the development and/or maintenance of basal forebrain cholinergic neurons
  • required for the patterning or the specification and differentiation of different cell types during embryonic development
  • SOHLH1 and LHX8 are two germ cell-specific, critical regulators of oogenesis
  • transcription factor involved in differentiation of certain neurons and mesenchymal cells
  • redundant activities of the LIM homeodomain proteins LHX6 and LHX8 are critical for craniofacial development and patterning of mammalian dentition
  • FIGLA, LHX8, NOBOX, SOHLH1, and SOHLH2 transcriptional regulators are critical for formation and maintenance of follicles
  • positive feedback regulation between LHX8, NTRK1, and NGF is likely an important regulatory mechanism for cholinergic functions of the septum
  • LHX8 is an important oocyte-specific transcription factor in the ovary for regulating postnatal folliculogenesis
  • major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • LHX8/SUV39H1 complex is inversely regulated by epithelium-mesenchymal signals, balancing the differentiation and proliferation of dental mesenchyme via H3K9 methylation
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • zinc ions Zn2+ binding
    • protein
  • likely LHX6 and LHX8 negatively regulate CDKN1C expression in the prospective palate area to allow adequate levels of cell proliferation and thereby promote normal palate development
    • cell & other
    REGULATION
    activated by FGF8 activated LHX8
    repressed by BMP2 repressed LHX8 expression at the transcriptional level
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for the isolated non syndromic form of cleft palate in humans (Zhao 1999)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with a null mutation of Lhx8 are deficient in development of forebrain cholinergic neurons (Zhao 2003)
  • in Lhx8 -/- mice, ovaries lacked germ cells and appeared histologically identical to adult Sohlh1 -/- ovaries (Pangas 2006)