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FLASH GENE

Symbol

LHX8

contributors: mct - updated : 24-03-2021

HGNC name	LIM homeobox 8
HGNC id	28838

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	33.10 kb     10 Exon(s)

regulatory sequence	Binding site   enhancer
text structure	enhancers (LHX8_enh1) located upstream of LHX8, is a key regulatory gene for craniofacial development

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001001933 10 - 2393 NP_001001933 - 356 - 2011 21143530 NM_001256114 8 - 2258 NP_001243043 - 346 - 2011 21143530

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two LIM zinc-binding domains
	one homeodomain

HOMOLOGY

interspecies	homolog to rattus lhx8 (97.2pc)
	homolog to murine Lhx8 (96.6pc)

Homologene

FAMILY

LIM homeobox gene family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome
text	(NOBOX) and LIM homeobox protein 8 (LHX8), two important regulators of postnatal oogenesis, were coexpressed with SOHLH1

basic FUNCTION	having a pivotal and specific role in the development and/or maintenance of basal forebrain cholinergic neurons
	required for the patterning or the specification and differentiation of different cell types during embryonic development
	SOHLH1 and LHX8 are two germ cell-specific, critical regulators of oogenesis
	transcription factor involved in differentiation of certain neurons and mesenchymal cells
	redundant activities of the LIM homeodomain proteins LHX6 and LHX8 are critical for craniofacial development and patterning of mammalian dentition
	FIGLA, LHX8, NOBOX, SOHLH1, and SOHLH2 transcriptional regulators are critical for formation and maintenance of follicles
	positive feedback regulation between LHX8, NTRK1, and NGF is likely an important regulatory mechanism for cholinergic functions of the septum
	LHX8 is an important oocyte-specific transcription factor in the ovary for regulating postnatal folliculogenesis
	major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

LHX8/SUV39H1 complex is inversely regulated by epithelium-mesenchymal signals, balancing the differentiation and proliferation of dental mesenchyme via H3K9 methylation

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc ions Zn2+ binding

protein

likely LHX6 and LHX8 negatively regulate CDKN1C expression in the prospective palate area to allow adequate levels of cell proliferation and thereby promote normal palate development

cell & other

REGULATION

activated by

FGF8 activated LHX8

repressed by

BMP2 repressed LHX8 expression at the transcriptional level

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene for the isolated non syndromic form of cleft palate in humans (Zhao 1999)
Marker
Therapy target

ANIMAL & CELL MODELS

	mice with a null mutation of Lhx8 are deficient in development of forebrain cholinergic neurons (Zhao 2003)
	in Lhx8 -/- mice, ovaries lacked germ cells and appeared histologically identical to adult Sohlh1 -/- ovaries (Pangas 2006)