basic FUNCTION
| constituting a novel core component of the mammalian DNA nonhomologous end-joining apparatus, might be involved in nonhomologous end-joining pathway of DNA double-strand break repair |
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acting as a novel DNA repair factor |
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plays a role in the development of the central nervous system |
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required for cellular survival in response to DNA double-strand break-generating agents |
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promotes the preservation of 3prime overhangs, restricts nucleotide loss and thereby promotes accuracy of DSB joining by XRCC4-DNA Ligase IV during NHEJ and V(D)J recombination |
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required for double-strand break (DSB) repair and V(D)J recombination |
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may serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends |
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may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini |
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acting in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary |
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role in repair of DSBs and maintenance of genomic stability under replication stress conditions |
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core protein of the nonhomologous end-joining pathway of DNA double-strand break repair |
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essential for gap filling by either polymerase during nonhomologous end joining, suggesting that it plays a major role in aligning the two DNA ends in the repair complex |
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XRCC4 and NHEJ1 filaments are suitable to align DNA molecules and function to facilitate LigIV end joining required for DSB repair |
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NHEJ1, ATM and H2AFX all have fundamental roles in processing and joining DNA ends during V(D)J recombination, but these roles have been masked by unanticipated functional redundancies |
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involved in the nonhomologous end-joining (NHEJ) process during DNA double-strand break (DSB) repair |
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influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis |
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in addition to end joining, TP53BP1 and NHEJ1 have overlapping functions in tumor suppression |
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DNA repair factor of the nonhomologous end-joining machinery |
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implicated in DSB pathway choice regulation, and is a non-essential, but critical, C-NHEJ-repair factor |
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XRCC4 and NHEJ1 are two structurally related proteins that function in DNA double-strand break (DSB) repair |