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FLASH GENE

Symbol

TGM3

contributors: mct/npt/shn - updated : 14-05-2015

HGNC name	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
HGNC id	11779

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

UHS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in esophageal squamous cell carcinoma (significantly inversely correlated with histological grade of esophageal carcinoma) (Liu 2006)

Susceptibility

to basal cell carcinoma

Variant & Polymorphism other	TGM3 (rs214782) confer risk of basal cell carcinoma

Candidate gene

Marker

Therapy target

corresponding disease(s)

UHS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in esophageal squamous cell carcinoma (significantly inversely correlated with histological grade of esophageal carcinoma) (Liu 2006)

Susceptibility

to basal cell carcinoma

Variant & Polymorphism other	TGM3 (rs214782) confer risk of basal cell carcinoma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS