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FLASH GENE
Symbol TGM3 contributors: mct/npt/shn - updated : 14-05-2015
HGNC name transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
HGNC id 11779
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly Mus musculusAdultNM_009374
 stomach   highly Mus musculusAdultNM_009374
Lymphoid/Immunespleen   moderately Mus musculusAdultNM_009374
Nervousbrainhindbraincerebellum moderately Mus musculusAdultNM_009374
Reproductivemale systemseminal vesicles  highly Mus musculusAdultNM_009374
Skin/Tegumentskin   highly Homo sapiensAdultNM_009374
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly Mus musculusAdultNM_009374
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • transglutaminase superfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the cross linking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds
  • involved the later stages of cell envelope formation in the epidermis and hair follicle
  • involved in terminal differentiation processes in the epidermis and contributing also to the physical resistance and the preservation of the hair follicle structure (Thibaut 2009)
  • involved in signal transduction and, like two other TGs (TGM2 and TGM5), is able to bind and hydrolyze guanosine triphosphate (Zocchi 2007)
  • plays a key role in production of the cornified envelope during epidermal differentiation
  • TGM2 (and possibly also TGM3, TGM7) gained vital functions which have not been fully revealed, yet
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Ca2+
    • protein
    cell & other
    REGULATION
    activated by proteolytic processing
    ASSOCIATED DISORDERS
    corresponding disease(s) UHS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in esophageal squamous cell carcinoma (significantly inversely correlated with histological grade of esophageal carcinoma) (Liu 2006)
    Susceptibility
  • to basal cell carcinoma
    • Variant & Polymorphism other
  • TGM3 (rs214782) confer risk of basal cell carcinoma
    • Candidate gene
    Marker
    Therapy target
    corresponding disease(s) UHS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in esophageal squamous cell carcinoma (significantly inversely correlated with histological grade of esophageal carcinoma) (Liu 2006)
    Susceptibility
  • to basal cell carcinoma
    • Variant & Polymorphism other
  • TGM3 (rs214782) confer risk of basal cell carcinoma
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS