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FLASH GENE
Symbol COQ2 contributors: mct/npt/shn - updated : 17-10-2010
HGNC name coenzyme Q2 homolog, prenyltransferase (yeast)
HGNC id 25223
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central polyprenyl diphosphate-binding site
  • 6 C-terminal transmembrane regions.
    • HOMOLOGY
    interspecies ortholog to Coq2, Mus musculus
    ortholog to Coq2, Rattus norvegicus
    ortholog to COQ2, Pan troglodytes
    Homologene
    FAMILY
  • ubiA prenyltransferase family
  • ubiquinone biosynthetic genes family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the synthesis of CoQ by catalysing the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group
  • major function is to transport electrons from complexes I and II to complex III in the respiratory chain which resides in the mitochondrial inner membrane (Quinzii 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text biosynthesis of ubiquinone
    PATHWAY
    metabolism
    signaling
  • part of the CoQ(10) biosynthetic pathways with ADCK3, PDSS2, PDSS1, COQ6, COQ9
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COQ10D1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • CoQ10 administration
    • ANIMAL & CELL MODELS