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FLASH GENE
Symbol COQ2 contributors: mct/npt/shn - updated : 17-10-2010
HGNC name coenzyme Q2 homolog, prenyltransferase (yeast)
HGNC id 25223
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrinepancreas   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central polyprenyl diphosphate-binding site
  • 6 C-terminal transmembrane regions.
    • HOMOLOGY
    interspecies ortholog to Coq2, Mus musculus
    ortholog to Coq2, Rattus norvegicus
    ortholog to COQ2, Pan troglodytes
    Homologene
    FAMILY
  • ubiA prenyltransferase family
  • ubiquinone biosynthetic genes family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the synthesis of CoQ by catalysing the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group
  • major function is to transport electrons from complexes I and II to complex III in the respiratory chain which resides in the mitochondrial inner membrane (Quinzii 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text biosynthesis of ubiquinone
    PATHWAY
    metabolism
    signaling
  • part of the CoQ(10) biosynthetic pathways with ADCK3, PDSS2, PDSS1, COQ6, COQ9
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COQ10D1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • CoQ10 administration
    • ANIMAL & CELL MODELS