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FLASH GENE
Symbol ASIP contributors: mct - updated : 03-02-2016
HGNC name agouti signaling protein, nonagouti homolog (mouse)
HGNC id 745
Location 20q11.21      Physical location : 32.848.170 - 32.857.148
Synonym symbol(s) AGT1, AH, ASP, MCIR, AGTIL, ASP, MGC126092, MGC126093, SHEP9
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - HCK - AH - RPN2 - ADA ADA - qter
Authors Kwon (94)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 584 - 132 - Sulem (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Reproductivemale systemprostate   
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five disulfide bonds
HOMOLOGY
interspecies homolog to murine agouti (A) signaling protein
Homologene
FAMILY agouti family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • melanocortin receptor (MC1R) antagonist
  • playing a role in hair or skin pigmentation and regulating the lipid metabolism within adipocytes
  • pharmacological antagonist of alpha-melanocyte-stimulating hormone
  • play a role in neuroendocrine aspects of melanocortin action
  • have a functional role in regulating lipid metabolism in adipocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , homeostasis
    text
  • energy homeostasis
  • appetite
  • PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein antagonizing MC4R
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to skin sensitivity to sun
  • to cutaneous melanoma (CM)
  • to facial pigmented spots during aging
  • Variant & Polymorphism other
  • pol 8818A -> G associated with dark hair and brown eyes
  • haplotype increasing the risk of cutaneous melanoma (CM)
  • genetic variations in ASIP, contribute to the acquired amount of facial pigmented spots during aging, through pathways independent of the basal melanin production
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS