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FLASH GENE
Symbol ZNRF4 contributors: mct - updated : 12-10-2011
HGNC name zinc and ring finger 4
HGNC id 17726
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one predicted transmembrane region separating an N-terminal protease-associated (PA) domain
  • three potential N-glycosylation sites (NXS) from a C-terminal RING finger domain (RING)
    • HOMOLOGY
    interspecies ortholog to murine Znrf4
    ortholog to rattus znrf4
    Homologene
    FAMILY Zn-finger family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text ER localization (subcellular fractionation revealed the presence of Nixin in the ER-enriched light membrane fraction together with the ER-localized protein calreticulin)
    basic FUNCTION
  • ubiquitin-protein ligase activity
  • central role for the regulation of calnexin (CANX)turnover
  • induces a proteasome-mediated degradation of calnexin
  • recognizes and ubiquitinates calnexin, which in turn would lead to the dislocation of CANX from the ER by VCP and subsequent degradation by the proteasome
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • physically interacts with CANX in a glycosylation-independent manner, induces calnexin ubiquitination, and VCP-dependent degradation, indicating an ER-associated degradation-like mechanism of calnexin turnover
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS