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FLASH GENE
Symbol ZWILCH contributors: mct - updated : 17-12-2014
HGNC name Zwilch, kinetochore associated, homolog (Drosophila)
HGNC id 25468
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Zwilch
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,chromatin/chromosome,kinetochore
text
  • localizes to kinetochores and kinetochore microtubules in a manner identical to ZW10 and KNTC1
    • basic FUNCTION
  • part of a complex necessary for accurate chromosome segregation, recruiting cytoplasmic dynein to the kinetochore and participating in the spindle checkpoint
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RZZ (KNTC1/ZW10/ZWILCH) complex is required for the recruitment of cytoplasmic dynein to kinetochores
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • weak interaction between the ZW10/KNTC1/ZWILCH complex and the kinesin-like kinetochore component CENPE
  • CCDC99 is a cell cycle-regulated mitotic phosphoprotein that interacts with the KNTC1/ZW10/ZWILCH (RZZ) complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS