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FLASH GENE
Symbol ZWILCH contributors: mct - updated : 17-12-2014
HGNC name Zwilch, kinetochore associated, homolog (Drosophila)
HGNC id 25468
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Reproductivefemale systemuteruscervix  
 male systemtestis   
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Zwilch
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,chromatin/chromosome,kinetochore
text
  • localizes to kinetochores and kinetochore microtubules in a manner identical to ZW10 and KNTC1
    • basic FUNCTION
  • part of a complex necessary for accurate chromosome segregation, recruiting cytoplasmic dynein to the kinetochore and participating in the spindle checkpoint
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RZZ (KNTC1/ZW10/ZWILCH) complex is required for the recruitment of cytoplasmic dynein to kinetochores
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • weak interaction between the ZW10/KNTC1/ZWILCH complex and the kinesin-like kinetochore component CENPE
  • CCDC99 is a cell cycle-regulated mitotic phosphoprotein that interacts with the KNTC1/ZW10/ZWILCH (RZZ) complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS