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FLASH GENE

Symbol

ZWILCH

contributors: mct - updated : 17-12-2014

HGNC name	Zwilch, kinetochore associated, homolog (Drosophila)
HGNC id	25468

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	44.40 kb     19 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001287821 19 - 3299 NP_001274750 - 477 - 2003 12686595 NM_001287822 18 - 3203 NP_001274751 - 477 - 2003 12686595 NM_017975 19 - 3204 NP_060445 - 591 - 2003 12686595 NM_001287823 18 - 3152 NP_001274752 - 477 - 2003 12686595

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Reproductive female system uterus cervix       male system testis       Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Zwilch

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome,kinetochore
text	localizes to kinetochores and kinetochore microtubules in a manner identical to ZW10 and KNTC1

basic FUNCTION

part of a complex necessary for accurate chromosome segregation, recruiting cytoplasmic dynein to the kinetochore and participating in the spindle checkpoint

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

RZZ (KNTC1/ZW10/ZWILCH) complex is required for the recruitment of cytoplasmic dynein to kinetochores

INTERACTION

DNA

RNA

small molecule

protein	weak interaction between the ZW10/KNTC1/ZWILCH complex and the kinesin-like kinetochore component CENPE
	CCDC99 is a cell cycle-regulated mitotic phosphoprotein that interacts with the KNTC1/ZW10/ZWILCH (RZZ) complex

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS