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FLASH GENE

Symbol

STEAP4

contributors: mct - updated : 04-06-2014

HGNC name	STEAP family member 4
HGNC id	21923

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	STEAP4-deficiency in mice leads to overt inflammation and development of spontaneous metabolic disease on a regular diet characterized by insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty liver disease (Kralisch 2009)
	loss of Steap4 expression in mice leads to increased production of inflammatory cytokines in visceral white adipose tissue and systemic insulin resistance